Tuesday, May 3, 2011
Scientists have identified a 'gene migraine', to raise new hope drug for headaches that bite and paralyze from the beginning.
Migraine included in the top 20 in the World Health Organisation disease that disables a person in his life and affects one in eight men and women. Migraine cause them more sick days than any other disease, with costs of more than 2 billion pounds a year. So that was launched from Hello Beautiful.
Although not known for sure the cause, migraine is estimated to occur due to hyperactivity of the brain electrical impulses that increase blood flow in the brain and result in brain blood vessel dilation and inflammation (inflammation).
Dilation and inflammation leads to pain and other symptoms, like nausea. More severe inflammation that occurs, the more severe migraine also suffered. Genetic factors play a role in the emergence generally highly migraine.
Severe headaches, which can be accompanied by nausea and visual disturbances, and sensitivity to light, could take up to three days passed. One in seven people believe that time off because of migraine has affected their careers.
With current drugs are ineffective or not suitable for all patients, the latest breakthrough could make conditions more likely to survive millions of migraine sufferers.
An international research team, led by experts from the Wellcome Trust Sanger Institute in Cambridge, comparing the DNA of thousands of people with migraine with others.
The team highlighted a genetic defect that appears to increase the likelihood of the disease with the use of glutamate, a chemical that sends messages to the brain, to build on the connections between brain cells.
Drugs that stop the glutamate from accumulating can stop the migraine, so according to the report the journal Nature Genetics.
Although recent research has identified genes associated with a rare form of migraine, has never had and found one of the most common conditions.
Dr Aarno Palotie, from the Sanger Institute, said, "This is the first time we've been able to peer into the genes of thousands of people and finding genetic clues to understanding the common migraine."
"Such studies are only possible through international cooperation on a large scale brings together the wealth of data with the expertise and appropriate resources so that we can choose the genetic variants. This discovery will open new doors to understanding human disease," he continued.
Professor Christian Kubisch, from the University of Ulm, Germany, said, "This study opens the way for new studies to look in depth at the biology of this disease and how these changes can be given effect."
Professor Peter Goadsby, representatives from the Migraine Trust, said: "The results of this study, people with migraine take us closer to understanding some fundamental aspects of chaos, implies an important chemical in the brain, glutamate, which activate nerve cells. The findings such as' bring hope 'for new research to find better treatments for migraine. "
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